Chemotherapy reshapes cellular clonal landscape via persister programs in breast cancer xenografts
Sarah Kronheim, J C M Wang, Jiao Yi Chen, Daniel Guerrero-Romero, Suet‐Feung Chin, Giulia Lerda, Allan J.W. Lui, Oscar M. Rueda, Federico Gaiti, Carlos Caldas, Long V. Nguyen
This study shows chemotherapy reshapes clonal architecture in breast cancer xenografts by selecting for chemotherapy-resistant clones and stress response programs.
bioRxiv · Apr 6, 2026 · PreprintCancer Biology