Ca2+-sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stress
Wei Chen, Madeline M. Motsinger, Jiaqian Li, Kevin P. Bohannon, Phyllis I. Hanson
The paper shows that ALG-2, a Ca2+ sensor, recruits ESCRTs to lysosomes to enhance their resilience against osmotic stress-induced rupture.
bioRxiv · Feb 4, 2024 · PreprintCell Biology