Diverse lung challenges elicit a conserved monocyte-to-macrophage differentiation blueprint
Chrysante S. Iliakis, Wouter T’Jonck, Isobel C. Mouat, Sam Bankole, Jiawei Liang, Gareth‐Rhys Jones, Justina Kulikauskaite, Matthew O. Burgess, Piotr P. Janas, Stefania Crotta, Simon Lawrence Priestnall, Alejandro Suárez‐Bonnet, Jürgen Schwarze, Andreas Wack, Calum C. Bain
The paper shows that monocyte-derived alveolar macrophages (mono-AMs) from different insults follow a conserved differentiation blueprint, while fetal-derived AMs show context-dependent changes.
bioRxiv · Mar 17, 2026 · PreprintImmunology