Simon Lawrence Priestnall

Diverse lung challenges elicit a conserved monocyte-to-macrophage differentiation blueprint

The paper shows that monocyte-derived alveolar macrophages (mono-AMs) from different insults follow a conserved differentiation blueprint, while fetal-derived AMs show context-dependent changes.

Branched actin networks mediate macrophage-dependent host microbiota homeostasis.

This study shows that Arpc5-containing Arp2/3 complexes are critical for macrophage function and maintaining host-microbiota homeostasis, as their loss leads to intestinal inflammation.

The penetrant chordoid glioma PRKCA mutation is an oncogenic gain-of-function kinase inactivation eliciting early onset chondrosarcoma in mice.

The PRKCA D463H mutation, an inactivating kinase mutation, acts as a gain-of-function oncogenic driver in mice, promoting chondrosarcoma through non-catalytic mechanisms.

PKN2 deficiency leads both to prenatal congenital cardiomyopathy and defective angiotensin II stress responses.

This study shows that PKN2 deficiency causes prenatal congenital cardiomyopathy and impairs angiotensin II-induced cardiac hypertrophy in adult mice.