Hypoimmunogenic human motor neurons induced from iPSCs in vivo substantially ameliorate ALS disease in large animal models
Na Zhang, Yang Yang, Mengqi Chen, Qingjian Zou, Longquan Quan, Jiayuan Huang, Quanjun Zhang, Yu Zhao, Zhen Ouyang, Zhongtian Zhang, Yuning Song, Min Chen, Kun Zhang, Amar Deep Sharma, Michael Ott, , Liangxue Lai
Hypoimmunogenic human motor neurons induced from iPSCs in vivo reform neuromuscular junctions and ameliorate ALS disease in pig and rabbit models.
bioRxiv · Sep 3, 2025 · PreprintNeuroscience