Na Zhang

PlantRegMoD: An integrative and AI-driven multi-omics database for plant regeneration research

PlantRegMoD is a multi-omics database for plant regeneration that integrates 20.54 TB of data from 147 projects across 32 species, offering tools for analysis and gene curation.

Cardiomyocytes upregulated PD-L1 expression to alleviate cardiac injury induced by irradiation combined with anti-PD-1 antibody: an in vitro and in vivo study

This study shows irradiation increases PD-L1 in cardiomyocytes, which may protect against cardiac injury by limiting inflammation and CD8 T-cell activity in mice.

The common evolution of fungicide persistence in cryptococcosis patients

The paper identifies common evolutionary events leading to fungicide persistence in Cryptococcus neoformans clinical isolates and shows ACO2 deficiency as a key predictor of high persistence.

Circadian misalignment underlies immune escape in breast cancer

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

Seeded aggregation of ANXA11 induces prion-like propagation, TDP-43 co-pathology and nucleocytoplasmic transport defects

This study shows ANXA11 forms prion-like amyloid fibrils through phase separation, which propagate between cells, induce TDP-43 pathology, and disrupt nucleocytoplasmic transport, linking ANXA11 dysfunction to ALS/FTD.

Hypoimmunogenic human motor neurons induced from iPSCs in vivo substantially ameliorate ALS disease in large animal models

Hypoimmunogenic human motor neurons induced from iPSCs in vivo reform neuromuscular junctions and ameliorate ALS disease in pig and rabbit models.

Co-Targeting IL-6 and EGFR signaling for the treatment of schwannomatosis and associated pain

This study identifies IL-6 and EGFR signaling as therapeutic targets for schwannomatosis, showing combined blockade reduces both pain and tumor growth in preclinical models.

Simple and rapid separation of diverse neoagaro-oligosaccharides

The paper describes a method to rapidly and simply separate diverse neoagaro-oligosaccharides using β-agarase from Vibrio natriegens, resulting in pure compounds with high purity.