Programming T cells for Early Cancer Detection with Customized Protease-Activatable Receptors
Hathaichanok Phuengkham, Ying Chen, Anirudh Sivakumar, Ali H. Zamat, Lena Gamboa, Quoc D. Mac, Hee Jun Lee, Leonard C. Rogers, Jicheng You, Sean A. Steele, Si-Chen Zhu, Matthew S Gollins, John Blazeck, Peng Qiu, Gabriel A. Kwong
This paper introduces OncoSCOUT, a method using engineered T cells with protease-activatable receptors to detect early-stage cancer with improved sensitivity compared to existing biomarkers.
bioRxiv · Jan 20, 2026 · PreprintBioengineering