Integration of microbial and chemical synthesis for the efficient production of plitidepsin, a promising anticancer and antiviral agent
Haili Zhang, Zhen Hui, Mingwei Cai, Shipeng Huang, Wenguang Shi, Mengdi Liang, Lin Yang, Jie Shen, Minghao Sui, Xuyang Li, Qiliang Lai, Jie Dou, Yun Ge, Min Zheng, Zongze Shao, , Xiaoyu Tang
This paper combines microbial and chemical synthesis to efficiently produce plitidepsin, achieving high yields and new analogues with anticancer and antiviral activities.
bioRxiv · Apr 24, 2023 · PreprintSynthetic Biology