Splicing factor SRSF1 is a pH-stat to restore nucleolar integrity and function
Suibin Ma, Jierui Guo, Xiang Zhan, Shuo Yang, Chaoqun Huang, Bo Wang
This study identifies SRSF1 as a pH-regulating factor that maintains nucleolar integrity by alkalizing the nucleolar microenvironment through its RS domain.
bioRxiv · Apr 12, 2025 · PreprintCell Biology