A hydrophobic core stabilizes the residual structure in the RRM2 intermediate state of the ALS-linked protein TDP-43
Brian C. Mackness, Brittany R. Morgan, Laura M. Deveau, Sagar V. Kathuria, Jill A. Zitzewitz, Francesca Massi
This study identifies a hydrophobic core stabilizing the RRM2 intermediate state of TDP-43, linking it to normal function and misfolding in ALS.
Journal of Molecular Biology · Jan 1, 2024Peer-reviewedBiochemistry