Author

Brian C. Mackness

University of Massachusetts Chan Medical SchoolORCID 0000-0002-3587-5603Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Abhinav GuptaiD· 1 shared Alexandra T. StariD· 1 shared Arsalan S. HaqqaniiD· 1 shared Bonnie BergeriD· 1 shared Brian J. SpenceriD· 1 shared Brittany R. MorganiD· 1 shared Bryan D. BrysoniD· 1 shared Byungje SungiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBioinformatics

Abhinav GuptaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A brain-shuttled antibody targeting alpha synuclein aggregates for the treatment of synucleinopathies

Sungwon An, John J. McInnis, Dongin Kim, Yihang Li, Ozge E. Tasdemir-Yilmaz, Jin-Hyung Ahn, Brian C. Mackness, Seung‐Hwan Kwon, Julia Maeve Bonner, Miran Yoo, Simon Dujardin, Donghwan Kim, Jin‐Young Park, Hyesu Yun, Yi Tang, , Can Kayatekin

This paper presents preclinical data on a bispecific antibody, SAR446159, designed to target alpha-synuclein aggregates and cross the blood-brain barrier for treating synucleinopathies.

npj Parkinson s Disease · Aug 22, 2025Peer-reviewedNeuroscience

Learning the Language of Antibody Hypervariability

Rohit Singh, Chiho Im, Yu Qiu, Brian C. Mackness, Abhinav Gupta, Taylor Joren, Samuel Sledzieski, Lena Erlach, Maria Wendt, Yves Fomekong‐Nanfack, Bryan D. Bryson, Bonnie Berger

This paper introduces AbMAP, a transfer learning framework for antibody sequence analysis, showing it can predict structure, binding, and paratope with high accuracy and enable antibody optimization.

Proceedings of the National Academy of Sciences · Dec 30, 2024Peer-reviewedBioinformatics

A hydrophobic core stabilizes the residual structure in the RRM2 intermediate state of the ALS-linked protein TDP-43

Brian C. Mackness, Brittany R. Morgan, Laura M. Deveau, Sagar V. Kathuria, Jill A. Zitzewitz, Francesca Massi

This study identifies a hydrophobic core stabilizing the RRM2 intermediate state of TDP-43, linking it to normal function and misfolding in ALS.

Journal of Molecular Biology · Jan 1, 2024Peer-reviewedBiochemistry