Francesca Massi

TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury

This study shows that TDP-43 dysfunction impairs proteostasis and worsens neurological outcomes after brain injury in mice.

A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability

This study identifies a conserved triple arginine motif in OMA-1 essential for RNA-binding and embryo viability in C. elegans.

Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

This study shows that ALS-linked PFN1 mutations impair vesicular degradation in iPSC-derived microglia by disrupting autophagy, which can be mitigated by Rapamycin.

A hydrophobic core stabilizes the residual structure in the RRM2 intermediate state of the ALS-linked protein TDP-43

This study identifies a hydrophobic core stabilizing the RRM2 intermediate state of TDP-43, linking it to normal function and misfolding in ALS.

A nematode model to evaluate microdeletion phenotype expression

This paper describes a microdeletion allele in C. elegans generated via CRISPR/Cas9, which removes 32 genes and causes complex developmental phenotypes.

Analysis of Rapidly Emerging Variants in Structured Regions of the SARS-CoV-2 Genome

The paper analyzes SARS-CoV-2 genomic sequences to identify rapidly emerging variants in structured cis-regulatory elements and their potential functional impacts.