A novel SXXLF motif in the FXR N-terminal domain mediates coregulator and interdomain interactions
Priscilla Villalona, Thilini Pulahinge, Tracy Yu, Jordan A. Wenning, Sabab Hasan Khan, Crawford Joseph Frisbie, Jill Magafas, Addison Barbe, C. Denise Okafor
This study identifies a novel SXXLF motif in the FXR N-terminal domain that mediates interactions with coregulators and the ligand binding domain, modulating transcriptional activity.
ChemBioChem · Sep 10, 2026Peer-reviewedBiochemistry