C. Denise Okafor

This study identifies a novel SXXLF motif in the FXR N-terminal domain that mediates interactions with coregulators and the ligand binding domain, modulating transcriptional activity.

The paper uses simulations to study the FXR-RXR heterodimer's structure and shows the hinge's role in DNA binding and interdomain allostery.

This study uses molecular dynamics simulations to show non-native interactions are critical for the inactive-to-active conformational transition in progesterone receptor.

This study uses computational and experimental methods to show that the hinge region of FXR mediates ligand-induced interdomain communication.

The paper identifies antimalarial compounds that inhibit ApiAP2 proteins in Plasmodium falciparum by screening small molecules against the AP2-EXP domain and validating their effects on parasite gene regulation and growth.

The paper demonstrates that Fe2+ cleaves RNA via a non-oxidative in-line mechanism, is more reactive than Mg2+, and is stably associated with ribosomes under anaerobic conditions.

The paper uses computational methods to analyze how ligand activation and evolutionary mutations affect allosteric networks in an ancestral steroid receptor, identifying key residues that modulate ligand specificity.