Developmental BiologybioRxivPreprint
A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling
Kanako Iwasaki, Priscila Carapeto, Cristian Abarca…·Cristina Aguayo‐Mazzucato
The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.