Priscila Carapeto

Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction

The paper identifies two distinct senescent β-cell subpopulations with different functional roles in islet aging and dysfunction using single-cell proteomics and transcriptomics.

A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

Sex-dependent additive effects of dorzagliatin and incretin on insulin secretion in a novel mouse model of GCK-MODY

This paper investigates sex-dependent effects of dorzagliatin and incretin on insulin secretion in a novel GCK-MODY mouse model, finding additive benefits in males but not females.

Bromodomain inhibition reveals FGF15/19 as a target of epigenetic regulation and metabolic control

The paper shows that inhibiting bromodomain proteins like BRD4 reduces FGF15/19 expression, leading to hyperglycemia, and that overexpressing FGF19 can reverse these effects.