Francisco G. Cigarroa

DIANNE enables rapid training and inference of spatial differential attributes in histology images without manual annotations, using mixup augmentation and foundation models.

The paper identifies two distinct senescent β-cell subpopulations with different functional roles in islet aging and dysfunction using single-cell proteomics and transcriptomics.

This study examines how high-fat and high-iron diets affect liver tumorigenesis and transcriptomic changes in mice, finding shared and distinct molecular effects.

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

This paper designs an ancestry informative marker panel using whole exome sequencing data to estimate genetic ancestry in Hispanic populations, achieving high accuracy in admixture proportion estimation.