Ayush D. Midha

Branched-chain amino acid fermentation as an alternative mammalian electron sink

This study identifies branched-chain amino acid fermentation as an alternative electron sink in mammals under hypoxia, with implications for reductive stress and sperm motility.

Red Blood Cells Serve as a Primary Glucose Sink to Improve Glucose Tolerance at Altitude

This study shows that red blood cells act as a primary glucose sink under hypoxia, improving glucose tolerance and offering therapeutic potential for diabetes.

Systemic hypoxia suppresses solid tumor growth

This study shows systemic hypoxia reduces solid tumor growth across multiple cancer types without resistance, through purine metabolism suppression and can be pharmacologically induced.

Genome-wide CRISPRi screen identifies basigin loss as protective in cardiac hypoxia

The paper uses a CRISPRi screen to identify basigin loss as protective in cardiac hypoxia by enhancing ATP maintenance and survival.

A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling

The paper identifies senescent β-cell subpopulations in humans and mice that induce pathologic dysfunction through paracrine signaling and shows JAK inhibitors can reverse this effect.

The single-molecule accessibility landscape of newly replicated mammalian chromatin

This study introduces RASAM, a method to analyze nascent chromatin structure, finding that newly replicated chromatin is hyperaccessible and has unique organization features.