Missing taxane C13α-O-deacetylases reveal a cryptic acetylation-deacetylation module in paclitaxel biosynthesis
Changkang Li, Xincheng Sun, Ridao Chen, Kebo Xie, Dawei Chen, Jimei Liu, Jungui Dai
The paper identifies and characterizes two novel C13-O-deacetylases and a C7β-O-deacetylase, demonstrating their role in paclitaxel biosynthesis and enabling a more efficient 19-gene pathway for baccatin III production.
bioRxiv · Aug 6, 2026 · PreprintBiochemistry