Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition
Jose Reyes, Isabella S. Del Priore, Andrea C. Chaikovsky, Nikhita Pasnuri, Ahmed M. Elhossiny, Jin Park, Philipp Weiler, Tobias Krause, Andrew R Moorman, Catherine Snopkowski, Meril T. Takizawa, Cassandra Burdziak, Nalin Ratnayeke, Ignas Masilionis, Yu-Jui Ho, , Scott W. Lowe
In mouse pancreatic cancer models, p53, CDKN2A and SMAD4 programs converge on a rare Kras-mutant progenitor-like state whose niche KRAS inhibition collapses and p53 loss expands.
Cell · Apr 15, 2026Peer-reviewedCancer Biology✦ In-depth digest