Endothelial lipase facilitates low-density lipoprotein (LDL) uptake in LDL receptor deficiency by a heparan sulfate proteoglycan-dependent mechanism.
Olivia White, Zahra Aligabi, Kendall H. Burks, Jingrong Tang, Nathan O. Stitziel, Ira J. Goldberg, Alan Thomas Remaley, Diego Lucero
This study shows endothelial lipase (EL) enables LDL uptake in LDLR-deficient cells via heparan sulfate proteoglycans, highlighting a new pathway for LDL cholesterol reduction.
bioRxiv · Mar 2, 2025 · PreprintPhysiology