Ira J. Goldberg

Extracellular vesicles from chylomicron-treated endothelial cells drive macrophage inflammation

This study shows that chylomicron-treated endothelial cells release extracellular vesicles that drive macrophage inflammation and lipid droplet formation.

Secretion and transfer of adipose lipoprotein lipase utilizes neutral sphingomyelinase 2 generated exosomes

This study identifies nSMase2-generated exosomes as a mechanism for adipocyte LPL secretion and transfer to endothelial cells via GPIHBP1.

Endothelial lipase facilitates low-density lipoprotein (LDL) uptake in LDL receptor deficiency by a heparan sulfate proteoglycan-dependent mechanism.

This study shows endothelial lipase (EL) enables LDL uptake in LDLR-deficient cells via heparan sulfate proteoglycans, highlighting a new pathway for LDL cholesterol reduction.

Inhibiting LXRα Phosphorylation in Hematopoietic Cells Reduces Inflammation and Attenuates Atherosclerosis and Obesity

This study shows that inhibiting LXRα phosphorylation in hematopoietic cells reduces inflammation and improves atherosclerosis and obesity by altering macrophage and adipose tissue gene expression.