Protein homeostasis imposes a barrier on functional integration of horizontally transferred genes in bacteria
Shimon Bershtein, Adrian Serohijos, Sanchari Bhattacharyya, Michael Manhart, Jeong-Mo Choi, Wangmen Mu, Jingwen Zhou, Eugene Shakhnovich
This study shows that protein homeostasis limits the functional integration of horizontally transferred genes in bacteria by reducing the abundance of foreign proteins, and that this barrier can be overcome through evolutionary adaptation.
bioRxiv · Sep 1, 2015Systems Biology