Jingwen Zhou

PromoR and PromoS for E. coli promoter recognition and classification

This study introduces two models, PromoR and PromoS, for promoter recognition and classification in E. coli, achieving accuracies of 0.887 and 0.781 respectively.

DUnet: A deep learning guided protein-ligand binding pocket prediction

DUnet predicts protein-ligand binding sites using a 3D convolutional neural network, outperforming existing methods and showing accuracy in industrial enzyme substrates.

Development of a growth coupled dynamic regulation network balancing malonyl-CoA node to enhance (2S)-naringenin synthesis in E. coli

The paper develops a dynamic regulation network in E. coli to balance malonyl-CoA for enhanced (2S)-naringenin synthesis, achieving an 8.4-fold production improvement with balanced growth.

Coupling metabolic addiction with negative autoregulation to improve strain stability and pathway yield

This paper improves strain stability and pathway yield in engineered yeast by coupling metabolic addiction with negative autoregulation.

Optimizing oleaginous yeast cell factories for flavonoids and hydroxylated flavonoids biosynthesis

This study optimizes Y. lipolytica for producing flavonoids and hydroxylated flavonoids by engineering metabolic pathways and enzyme modules.