Amelioration of signalling deficits underlying metabolic shortfall in TREM2R47H human iPSC-derived microglia
Foteini Vasilopoulou, Thomas M. Piers, Jingzhang Wei, John Hardy, Jennifer M. Pocock
This study investigates how metabolite supplementation affects metabolic and functional deficits in TREM2-mutant human iPSC-derived microglia, identifying distinct effects of citrate and succinate on mitochondrial function and phagocytosis.
bioRxiv · Feb 12, 2024 · PreprintNeuroscience