Targeting Galectin-3 to modulate inflammation in LAMA2-deficient congenital muscular dystrophy
Yonne Karoline Tenório de Menezes, Jinseo Lee, Jia Qi Cheng-Zhang, Marie A. Johnson, Ruvindi N. Ranatunga, Dwi U. Kemaladewi
This study identifies Galectin-3 as a driver of inflammation in LAMA2-CMD and shows that inhibiting it reduces inflammation and fibrosis in a mouse model.
bioRxiv · Mar 12, 2025 · PreprintImmunology