H2O2-induced astrocytic collagen triggers neuronal death via fucosylation-dependent glial barrier formation upon ischemic stroke
Jae‐Hun Lee, Hyun Jun Jang, In-Young Hwang, Jiwoon Lim, Jiwoong Jung, Myungju Kim, Eunji Lee, Woojin Won, Elijah Hwejin Lee, Ki Jung Kim, Ki Duk Park, Woonggyu Jung, Boyoung Lee, Seungjun Ryu, Changjoon Justin Lee
This study identifies H2O2-induced astrocytic collagen production as a mechanism causing neuronal death in ischemic stroke, with potential therapeutic targets identified.
bioRxiv · May 1, 2025 · PreprintNeuroscience