Ki Duk Park

This study identifies the astrocytic MAOB-GABA axis as a brake on spinal cord injury repair and shows that the inhibitor KDS2010 promotes recovery in animal models and has a safe profile in humans.

This study identifies H2O2-induced astrocytic collagen production as a mechanism causing neuronal death in ischemic stroke, with potential therapeutic targets identified.

This paper identifies hemoglobin as a peroxidase with therapeutic potential for oxidative stress-related diseases and presents KDS12025 as a drug candidate that enhances its activity.

This study identifies GABRA5-positive neurons in the lateral hypothalamic area that regulate obesity through astrocytic GABA release, showing that inhibiting astrocytic GABA reduces weight gain.

The paper demonstrates that PET/CT imaging with 11C-acetate and 18F-FDG can visualize reactive astrocyte-mediated neuronal hypometabolism in Alzheimer's disease.

The paper uses intravital imaging to study cellular changes after cerebral microinfarction in mice, finding that astrocyte reactivity leads to glial scar formation.

The paper identifies a novel CaV2.2 channel antagonist with broad antinociceptive effects and reduced side effects in pain models.