Jiwoon Lim

This study identifies H2O2-induced astrocytic collagen production as a mechanism causing neuronal death in ischemic stroke, with potential therapeutic targets identified.

This paper identifies hemoglobin as a peroxidase with therapeutic potential for oxidative stress-related diseases and presents KDS12025 as a drug candidate that enhances its activity.

This study identifies GABRA5-positive neurons in the lateral hypothalamic area that regulate obesity through astrocytic GABA release, showing that inhibiting astrocytic GABA reduces weight gain.

This study investigates the role of PAT/SAT1 in MAO-B-dependent GABA synthesis in astrocytes, showing that PAT/SAT1 gene silencing reduces GABA synthesis and tonic inhibition.

This study identifies TMEM43 as a pH-sensing cation channel that modulates gap junction networks in the hippocampus, preventing neuronal hyperexcitability and supporting memory retrieval.

This study shows that astrocytic urea cycle detoxifies Aβ-derived ammonia but impairs memory in Alzheimer's disease, suggesting ODC1 inhibition as a potential therapeutic strategy.