Targeting the energy metabolism of melanoma cells: FX-11 acts as a mitochondrial uncoupler
Jasmin Renate Preis, Catherine Rolvering, Mélanie Kirchmeyer, Catarina Tinoco Pereira, João Faria, Iris Behrmann, Claude Haan
This paper identifies FX-11 as a mitochondrial uncoupler that inhibits melanoma cell growth, including drug-resistant sublines, by altering energy metabolism rather than targeting lactate dehydrogenase.
European Journal of Pharmacology · Mar 25, 2026Peer-reviewedCancer Biology