Microaerobic Copper Stress Redirects Pyruvate Metabolism and Reveals a CopL-linked Nitrogen Response in Staphylococcus aureus.
Sean Brennan, Inderpreet Kaur, Daniella Lucy Spencer, Joanne Purves, Hannah R. Sampson, Julian M. Ketley, Joan Geoghegan, Peter William Andrew, Kevin John Waldron, Julie A. Morrissey
This study shows that microaerobic copper stress in S. aureus redirects pyruvate metabolism and activates a CopL-linked nitrogen response, enhancing bacterial fitness in host environments.
bioRxiv · Jun 18, 2026 · PreprintMicrobiology