Author

Sean Brennan

University of Leicester

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Ahmed S.A. MadyiD· 1 shared Alison J DavisiD· 1 shared Antony J. BurtoniD· 1 shared Barry J. Teobald· 1 shared Berent Lundeen· 1 shared Bharti Patel· 1 shared Bryan W. DorseyiD· 1 shared Daniella Lucy Spencer· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

Ahmed S.A. MadyORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Microaerobic Copper Stress Redirects Pyruvate Metabolism and Reveals a CopL-linked Nitrogen Response in Staphylococcus aureus.

Sean Brennan, Inderpreet Kaur, Daniella Lucy Spencer, Joanne Purves, Hannah R. Sampson, Julian M. Ketley, Joan Geoghegan, Peter William Andrew, Kevin John Waldron, Julie A. Morrissey

This study shows that microaerobic copper stress in S. aureus redirects pyruvate metabolism and activates a CopL-linked nitrogen response, enhancing bacterial fitness in host environments.

bioRxiv · Jun 18, 2026 · PreprintMicrobiology

Chemoproteomics discovery of a CNS-penetrant covalent inhibitor of PIKfyve

Antony J. Burton, Louis S. Chupak, Alison J Davis, Ahmed S.A. Mady, Mirco Meniconi, Barry J. Teobald, Bryan W. Dorsey, Lauren R Byrne, Ryan M. Mulhern, Berent Lundeen, Elizabeth W. Sorensen, Bharti Patel, Sean Brennan, Dhiraj Kormocha, Rubén Tommasi, , Elayne Chan-Penebre

This paper discovers and optimizes a CNS-penetrant covalent inhibitor of PIKfyve, DUN058, showing sustained target occupancy and modulation of protein clearance pathways in vivo.

bioRxiv · Jan 28, 2026 · PreprintBiochemistry