The fitness cost of mis-splicing is the main determinant of alternative splicing patterns
Baptiste Saudemont, Alexandra Popa, Joanna L. Parmley, Vincent Rocher, Corinne Blugeon, Anamaria Necşulea, Éric Meyer, Laurent Duret
The paper quantifies the fraction of alternative splicing events that are errors by analyzing transcriptomes of Paramecium tetraurelia and humans, finding that 92%-98% of splice variants in medium-expressed genes are errors.
Genome biology · Oct 30, 2017Peer-reviewedGenomics