Baptiste Saudemont

OLD sentinel: an abortive tRNase surveys phage replication and DNA defects in RecBCD-compromised cells

This paper characterizes OLD, an abortive immunity protein, revealing its structure and activation mechanism in response to phage replication and DNA defects in RecBCD-compromised cells.

Specificity and Mechanism of tRNA cleavage by the AriB Toprim nuclease of the PARIS bacterial immune system

The paper identifies additional tRNA targets of the AriB nuclease in the PARIS system and shows that phage-encoded tRNAs can inhibit this defense.

TATTOO-seq delineates spatial and cell type-specific regulatory programs during limb patterning

This study uses TATTOO-seq to identify spatial and cell type-specific regulatory programs during limb development and shows how perturbations affect cell fate and spatial organization.

The fitness cost of mis-splicing is the main determinant of alternative splicing patterns

The paper quantifies the fraction of alternative splicing events that are errors by analyzing transcriptomes of Paramecium tetraurelia and humans, finding that 92%-98% of splice variants in medium-expressed genes are errors.