Vincent Rocher

The paper examines chromatin accessibility changes at DNA double-strand breaks (DSBs) in single cells, revealing resection-dependent remodeling and associated gene expression programs.

The paper identifies PERIOD proteins as regulators of TC-DSB repair by anchoring DSBs to the nuclear envelope, linking circadian rhythms to DNA repair mechanisms.

The paper identifies a new class of non-coding variants, dsbSNPs, that modulate DNA double-strand break frequency and are enriched in GWAS associations for complex diseases.

This study investigates how propionic acid affects anaerobic digestion by comparing its effects to sodium propionate and NaCl, showing acidity is the main inhibitor.

The paper identifies a novel chromatin compartment formed by ATM-dependent clustering of damaged TADs, which enhances DNA damage response but increases translocations.

The paper identifies TADs as functional units in DDR, showing cohesin-mediated loop extrusion contributes to {gamma}H2AX/53BP1 domain formation during DSB repair.

DeepG4 accurately predicts active G-quadruplexes in DNA using a convolutional neural network, identifying key motifs and showing their impact on transcription and chromatin.

This study shows BLM promotes Homologous Recombination at DSBs in active chromatin but switches to Break-Induced Replication when R-loop dissolution is impaired, reducing cell viability.

The paper quantifies the fraction of alternative splicing events that are errors by analyzing transcriptomes of Paramecium tetraurelia and humans, finding that 92%-98% of splice variants in medium-expressed genes are errors.