Developmental and molecular features shaping broad and synergistic actions of human autoantibodies targeting interferon-α
Kevin Groen, Jacques A Moritz, Sheena Vasquez, Adonis A. Rubio, Roger Kuratli, David Jones, Deborah Grafl, Maddalena Motta, Stefano Fontana, Joanna Manning, Simone Costagli, Luca Simonelli, Roshan Singh Thakur, David Jarrossay, Chau Tran, , Benjamin G. Hale
This study tracks the development of human autoantibodies against interferons over time, revealing their maturation, specificity, and synergistic effects in blocking IFN signaling.
bioRxiv · Oct 25, 2026 · PreprintImmunology