Luca Simonelli

Developmental and molecular features shaping broad and synergistic actions of human autoantibodies targeting interferon-α

This study tracks the development of human autoantibodies against interferons over time, revealing their maturation, specificity, and synergistic effects in blocking IFN signaling.

Human antibodies against West Nile and related orthoflaviviruses

The paper identifies two human monoclonal antibodies that neutralize West Nile virus and related orthoflaviruses, offering potential for antibody-based interventions.

A conformational switch controlling the toxicity of the prion protein

This study identifies an H-latch conformational switch in PrPC that drives prion toxicity and shows that disrupting this switch can protect against prion-related neurodegeneration.

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity

This paper introduces a bispecific antibody that targets both the globular domain and flexible tail of PrP, preventing prion toxicity and oligomer formation.