Benjamin G. Hale

Developmental and molecular features shaping broad and synergistic actions of human autoantibodies targeting interferon-α

This study tracks the development of human autoantibodies against interferons over time, revealing their maturation, specificity, and synergistic effects in blocking IFN signaling.

Influenza A virus NS1 sequesters RNA:DNA hybrids to evade RNase H1-dependent innate immunity

Human antibodies against West Nile and related orthoflaviviruses

The paper identifies two human monoclonal antibodies that neutralize West Nile virus and related orthoflaviruses, offering potential for antibody-based interventions.

SP110 sequestration of SP100 protects against toxic filaments during innate immune signaling

The paper identifies SP110 as a negative regulator of type 1 interferon-driven cell death by counteracting SP100's toxic filament formation through CARD domain interactions.

TRIM28 is a target for paramyxovirus V proteins

This paper shows that paramyxovirus V proteins interact with TRIM28, preventing its SUMO modification loss and ERE activation, thereby suppressing antiviral immune responses.

Influenza A Virus NS1 Limits Recognition of Double-Stranded Transposable Elements by Cytosolic RNA Sensors

This study shows that IAV NS1 prevents cytosolic recognition of dsRNA from host transposable elements by binding to them, limiting innate immune activation.

An Atlas of Protein Phosphorylation Dynamics During Interferon Signaling

The paper maps phosphorylation dynamics during interferon signaling, identifying over 700 phosphorylation events and their roles in antiviral responses.

Highly-sensitive reporter cell line for detection of interferon types I-III and their neutralization by antibodies

The paper develops a highly sensitive Renilla luciferase-based reporter cell line to detect IFN types I-III and neutralizing antibodies.