Geometrically encoded positioning of introns, intergenic segments, and exons in the human genome
Luay Matthew Almassalha, Kyle L. MacQuarrie, Marcelo A. Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert J. Nap, Parambir Singh Dulai, Igal G. Szleifer, Vadim Backman
The paper proposes that introns, intergenic segments, and exons are positioned geometrically within chromatin domains to sustain transcriptional memory and reconcile epigenetic patterns and mutation non-randomness.
Advanced Science · Oct 27, 2025Peer-reviewedBiophysics