Author

Rikkert J. Nap

Northwestern UniversityORCID 0000-0002-1809-0249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

Igal G. SzleiferiD· 3 shared Vadim BackmaniD· 3 shared Cody L. DuntoniD· 2 shared Luay Matthew AlmassalhaiD· 2 shared Paola Carrillo GonzaleziD· 2 shared Ranya K. A. VirkiD· 2 shared Ruyi GongiD· 2 shared Wing Shun LiiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

Igal G. SzleiferORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Geometrically encoded positioning of introns, intergenic segments, and exons in the human genome

Luay Matthew Almassalha, Kyle L. MacQuarrie, Marcelo A. Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert J. Nap, Parambir Singh Dulai, Igal G. Szleifer, Vadim Backman

The paper proposes that introns, intergenic segments, and exons are positioned geometrically within chromatin domains to sustain transcriptional memory and reconcile epigenetic patterns and mutation non-randomness.

Advanced Science · Oct 27, 2025Peer-reviewedBiophysics

Leveraging chromatin packing domains to target chemoevasion in vivo

Jane Frederick, Ranya K. A. Virk, I Chae Ye, Luay Matthew Almassalha, Greta Wodarcyk, David VanDerway, Ruyi Gong, Cody L. Dunton, Tiffany Kuo, Karla Medina, Margarita Loxas, Jared T. Ahrendsen, Demirkan Besim Gursel, Paola Carrillo Gonzalez, Rikkert J. Nap, , Vadim Backman

This study develops a physics-based model linking chromatin organization to chemoevasion, identifies TPR compounds that enhance chemotherapy efficacy in ovarian cancer.

Proceedings of the National Academy of Sciences · Jul 22, 2025Peer-reviewedBiophysics

The Impact of Charge Regulation and Ionic Intranuclear Environment on the Nucleosome Core Particle

Rikkert J. Nap, Paola Carrillo Gonzalez, A. E. Coraor, Ranya K. A. Virk, Juan Pablo, Vadim Backman, Igal G. Szleifer

This study theoretically examines how intranuclear factors like salt concentration and pH affect the charge state of nucleosome core particles, highlighting the role of magnesium ions and molecular details.

The Journal of Chemical Physics · Dec 20, 2024Peer-reviewedBiophysics