Wing Shun Li

The paper shows that Pol-II regulates chromatin packing domains through transcriptional loops, linking RNA synthesis to genome organization and gene expression.

The paper proposes that introns, intergenic segments, and exons are positioned geometrically within chromatin domains to sustain transcriptional memory and reconcile epigenetic patterns and mutation non-randomness.

This study develops a physics-based model linking chromatin organization to chemoevasion, identifies TPR compounds that enhance chemotherapy efficacy in ovarian cancer.

This paper develops a three-color single-molecule localization microscopy protocol to study chromatin structure, revealing that heterochromatin and euchromatin are not distinct territories but are spatially coupled.

The paper shows that RNA polymerase I co-regulates chromatin domains and mRNA synthesis with RNA polymerase II, affecting genome connectivity and gene expression.

The paper shows that RAD21 depletion reduces but does not eliminate chromatin packing domains in electron microscopy, suggesting non-cohesin mechanisms largely control 3D structure.

The paper introduces ChromSTEM, a method for high-resolution 3D imaging of chromatin structure, and finds that chromatin forms well-defined domains around 100 nm in radius with radially decreasing mass-density.