Astrocyte plasticity ensures continued endfoot coverage of cerebral blood vessels and integrity of the blood brain barrier, with plasticity declining with normal aging.
William A. Mills, Shan Jiang, Joelle Martin, AnnaLin M. Woo, Matthew Bergstresser, Ian F. Kimbrough, Harald W. Sontheimer
This study shows astrocyte plasticity maintains vascular coverage and BBB integrity by replacing ablated astrocytes, but this plasticity declines with aging.
bioRxiv · May 8, 2021 · PreprintNeuroscience