Harald W. Sontheimer

The paper uses multi-region recordings in mice to show that gamma communication between hippocampal CA3 and amygdala collapses abruptly at seizure onset.

The paper identifies sex- and brain region-specific pericyte signaling changes in Alzheimer's Disease using single-nucleus RNA sequencing and spatial transcriptomics.

This study shows that microenvironment T-type calcium channels promote glioblastoma growth by regulating neuronal and glial processes, and that blocking these channels with mibefradil enhances the effectiveness of standard therapies.

This study shows that Aβ deposition in meningeal arteries correlates with reduced cerebral blood flow and collateral vessel remodeling in a mouse model of AD, with sex differences in Aβ burden.

This study identifies increased chondroitin sulfate proteoglycans (CSPGs) in the hippocampus and amygdala as a cause of infection-induced epilepsy, showing their role in neuronal hyperexcitability and potential as a therapeutic target.

This study uses zebrafish to investigate glial-vascular interactions during CNS development, showing conserved lineage-specific roles in vessel maintenance and formation.

This study shows astrocyte plasticity maintains vascular coverage and BBB integrity by replacing ablated astrocytes, but this plasticity declines with aging.

The paper shows pericytes communicate with endothelial cells during vasculogenesis via Cx43 gap junctions, using mouse embryonic stem cells and live imaging.