Mice with Reduced PAR4 Reactivity show Decreased Venous Thrombosis and Platelet Procoagulant Activity
Elizabeth A. Knauss, Johana Guci, Norman F. Luc, Dante Disharoon, Grace H. Huang, Anirban Sen Gupta, Marvin T. Nieman
This study shows that mice with a PAR4 mutation (PAR4-P322L) have reduced venous thrombosis and platelet procoagulant activity due to decreased phosphatidylserine exposure and thrombin generation.
Journal of Thrombosis and Haemostasis · Jan 9, 2025Peer-reviewedPhysiology