Marvin T. Nieman

This study shows that platelet PAR4 signaling, interacting with estrogen receptor beta, drives glioblastoma progression and immune suppression, with sex-specific effects on survival and TME dynamics.

This paper develops a nonviral, ultrasound-triggered gene delivery platform using cationic nanobubbles that achieve efficient, site-specific gene expression in vitro and in vivo.

This paper uses cryo-EM with the Build-and-Retrieve method to solve integrin αIIbβ3 structures from resting human platelet membranes, revealing new insights into its regulation and dimer conformation.

This study shows that mice with a PAR4 mutation (PAR4-P322L) have reduced venous thrombosis and platelet procoagulant activity due to decreased phosphatidylserine exposure and thrombin generation.

This paper presents three structures of PfNCR1, a Plasmodium falciparum membrane protein, and shows it exports cholesterol to maintain membrane homeostasis, with MMV009108 inhibiting this function.

The paper develops a PAR3 agonist and shows it induces mechanical hypersensitivity in mice, suggesting PAR3's role in nociception and plasticity.