Chronic optogenetic activation of hippocampal pyramidal neurons replicates the proteome footprint of Alzheimer's disease-like pathology
Iason Keramidis, Martina K. Samiotaki, Romain Sansonetti, Johanna Alonso, Patrick Desrosiers, Katerina Papanikolopoulou, Yves De Koninck
The paper shows that sustained neuronal hyperactivity in wild-type and AD-like mice leads to proteomic changes similar to AD pathology, including memory loss and increased Aβ42 secretion.
iScience · Aug 28, 2025Peer-reviewedNeuroscience