Martina K. Samiotaki

This study identifies cholinergic neurons as the key circuit for Neurofibromin-regulated sleep consolidation in Drosophila NF1 models, revealing Ras/MAPK signaling dysregulation and mutation-specific mechanisms.

The paper shows that RpS12 induces the Xrp1short isoform in Rp+/- cells, which is necessary and sufficient for their elimination, challenging existing models of ribosomal protein-linked fitness surveillance.

This study shows that loss of normal Tau function in the adult brain causes neuronal atrophy, epigenetic changes, and cognitive/mood deficits, which can be reversed by Tau re-expression or epigenetic correction.

The paper investigates how ERAP1 allotypes 2 and 10 affect the immunopeptidome of melanoma cells, finding quantitative changes in peptide abundance rather than sequence differences.

This study identifies Mena as a regulator of local protein synthesis in adult axons, showing it controls PI3K-p85 mRNA translation and axon regeneration after injury.

The paper shows that sustained neuronal hyperactivity in wild-type and AD-like mice leads to proteomic changes similar to AD pathology, including memory loss and increased Aβ42 secretion.

This study identifies an alternative splicing program regulated by SRRM3 that affects secretory function and neuronal characteristics in PanNETs, offering therapeutic targets.

This study shows that ERAP1 inhibition alters the immunopeptidome and proteome in cancer cells, affecting metabolism and stress responses, but only a small fraction of proteomic changes impact the immunopeptidome.

This study shows exercise induces anti-inflammatory reprogramming in macrophages via Hsp60, identified through secretome analysis and proteomic profiling.

This study uses cerebral organoids to show that CNTNAP2 loss causes imbalanced GABA/glutamate neuron differentiation and increased AKT/mTOR signaling, linked to ASD pathophysiology.

This study shows that p.A53T-α-Synuclein astrocytes from Parkinson's patients impair proteostasis, leading to neurodegeneration and Lewy-like pathology in co-cultured neurons.

The paper shows IQGAP1 regulates NDUFS4 alternative splicing, affecting mitochondrial complex I function in gastric cancer cells.

The paper identifies a kinase inhibitor, BX795, that rescues pathological phenotypes in a patient-derived Parkinson's disease model through proteomic analysis and high-content screening.