Intersectin and Endophilin condensates prime synaptic vesicles for release site replenishment
Tyler H Ogunmowo, Christian Hoffmann, Chintan Patel, Renee Pepper, huili wang, Sindhuja Gowrisankaran, Johanna Idel, A S Ho, Sumana Raychaudhuri, Brady J. Maher, Benjamin H. Cooper, Ira Milošević, Dragomir Milovanović, Shigeki Watanabe
The paper shows that Intersectin-1 and Endophilin A1 form condensates near synaptic release sites to cluster replacement vesicles, enabling rapid replenishment of neurotransmitter release sites.
Nature Neuroscience · Jul 8, 2025Peer-reviewedNeuroscience