Benjamin H. Cooper

SynapseNet automatically segments synapses in electron micrographs using deep learning, enabling efficient analysis of synaptic structures.

The paper shows that Intersectin-1 and Endophilin A1 form condensates near synaptic release sites to cluster replacement vesicles, enabling rapid replenishment of neurotransmitter release sites.

The paper introduces NbLumSyt1 nanobinders for analyzing synaptic vesicle dynamics in rodent and human models with improved precision and versatility.

The paper uses cryo-electron tomography to study synaptic vesicle tethering and priming, revealing the role of Munc13 and SNAP25 in confining vesicles and guiding fusion.

The paper identifies a novel ECM remodeling mechanism through endocytosis and resurfacing of Tenascin-R near synapses, occurring within 3 days and dependent on activity.

The paper identifies key proteins and domains involved in dopamine release in the striatum, showing that RIM, Munc13, and Liprin- are essential while other active zone proteins are not.

The paper investigates serotonin release mechanisms from mouse enterochromaffin cells using multiple techniques and finds that serotonin is primarily released from large dense-core vesicles with slow kinetics, similar to other endocrine cells.

This study investigates the roles of synaptotagmin-1 and synaptotagmin-7 in Ca2+-dependent vesicle priming and exocytosis in mouse chromaffin cells, showing their synergistic effects.

The paper investigates ultrastructural differences between Schaffer collateral and mossy fiber synapses to determine their contribution to functional synaptic heterogeneity.

This study identifies Complexin as a conserved vesicular protein that interacts with Bruchpilot's C-terminus to tether synaptic vesicles to the active zone cytomatrix in Drosophila and mouse synapses.