Brady J. Maher

The paper identifies distinct DNA methylation mechanisms for common and rare noncoding genetic risk in brain disorders using deep learning and single-nucleus DNAm data.

The paper uses image-based profiling of hiPSC-derived trophoblasts to identify SCZ risk signatures linked to sex, placental genomic risk, and hypoxic stress.

This study investigates the effect of germline TCF4 mutations on astrocyte lineage in a Pitt-Hopkins Syndrome mouse model, finding no significant impact on astrocyte markers or distribution.

The paper shows that Intersectin-1 and Endophilin A1 form condensates near synaptic release sites to cluster replacement vesicles, enabling rapid replenishment of neurotransmitter release sites.

This paper introduces automated high-throughput patch clamp electrophysiology methods for hiPSC-derived neurons, enabling efficient analysis of voltage-gated sodium channels and pharmacological responses.

The paper analyzes transcriptomic and proteomic data from specific brain regions to identify molecular changes in schizophrenia, showing superior regional discrimination in transcriptomic and proteomic data.

This study shows TCF4 mutations impair synaptic function in patient-derived cortical neurons by disrupting RIMBP2 expression, leading to deficits in synaptic transmission and network excitability.

CaPTure is a scalable pipeline for analyzing calcium imaging data from cultured neurons, enabling high-throughput phenotypic discovery.

The paper evaluates Nav1.8 as a therapeutic target for Pitt Hopkins Syndrome by reviewing literature and presenting data showing its inhibition normalizes neuron function and behavior in mouse models.

The paper identifies electrophysiological measures in hiPSC-derived neurons linked to schizophrenia diagnosis and cognitive performance.

The paper identifies a distinct population of hippocampal neurons projecting to the prelimbic cortex that regulate context fear memory recall through molecular and circuit-specific mechanisms.

The paper uses hiPSC transcriptomics to study neuronal differentiation and maturation across multiple conditions and develops a tool to estimate neuronal maturity.

The paper identifies 237 genes associated with schizophrenia using RNA sequencing and eQTL analysis, showing enrichment for developmentally regulated synaptic genes.

The paper compares mouse models of syndromic ASD with human ASD brain data to identify shared myelination and axon development disruptions across both syndromic and idiopathic ASD.